Cadence, a clinical AI company managing chronic care for older adults, raised $100 million in a Series C funding round led by Spark Capital. The investment aims to scale AI agents to address the needs of over 56 million older adults with chronic disease amid a deepening clinician shortage. Cadence treats more than 100,000 active patients and tripled its annual recurring revenue in 2025.

The round included participation from Thrive Capital, General Catalyst, Coatue, B Capital, Corewell Health Ventures, Memorial Hermann, and Duke Health. Will Reed, partner at Spark Capital, will join Cadence's board. The company announced new affiliations with Duke Health and Texas Health Resources, expanding its partnerships to over 20 leading health systems.

Cadence's Clinical Intelligence integrates directly into partner health systems' electronic medical records and clinical workflows. Supervised AI agents monitor patient vitals daily, support medication adjustments, and provide lifestyle coaching. The system reports a median response time of 3.5 minutes for incoming vitals alerts, with 55% resolved without human adjustment.

The company's model has demonstrated significant clinical outcomes and cost savings. Peer-reviewed studies indicate a 230% increase in heart failure patients on guideline-directed medical therapy and a 70% relative increase in blood pressure control for hypertension patients. Additionally, the model achieved a 27% reduction in hospital admissions and a $1,302 per-patient annual reduction in total cost of care.

Cadence's Remote Patient Care model returns more than $3 to Medicare for every dollar spent, saving the program roughly $2.7 million weekly. With the new capital, Cadence plans to expand across new health systems, advance its AI agents, and grow value-based care models.

Cadence Design Systems has outperformed the market over the past 10 years by 18.25% on an annualized basis, producing an average annual return of 31.73%. The company currently has a market capitalization of $107.94 billion.

An investment of $100 in Cadence Design Systems stock 10 years ago would be worth $1,594.85 today, based on a price of $390.94 for the stock at the time of writing. This performance highlights the significant impact compounded returns can have on cash growth over a period of time.

Performance Metrics

The following table details the key performance metrics for Cadence Design Systems over the last decade: