Iran’s national security chief warned Gulf neighbors Saturday that joining Washington’s economic pressure campaign would designate them as enemies. Mohsen Rezaei stated Tehran would target the interests of participating countries.

The remarks aired on state broadcaster IRIB, citing Rezaei’s threat to escalate beyond targeting military bases if further US sanctions are imposed. This follows President Donald Trump’s campaign to isolate Iran’s economy, which he claims will have tremendous consequences for trading partners.

Rezaei Raises Stakes for Gulf Energy Trade

Rezaei, a former Revolutionary Guard commander and key adviser to Supreme Leader Ayatollah Mojtaba Khamenei, replaced Mohammad Bagher Zolghadr as secretary of the security council this month. He previously ran unsuccessfully for president.

Last week, Rezaei stated via X that the Strait of Hormuz would reopen only when the US ends the war and blockade, releases Iran’s frozen assets, and agrees to a region-wide ceasefire in Lebanon and Gaza.

Trump Pushes Economic Isolation Campaign

Trump has repeatedly called the Strait of Hormuz "new U.S. territory," a claim with no legal standing. The strait remains a critical bottleneck for roughly a fifth of global oil supply, keeping crude markets on edge.

Regional uncertainty has deepened with no signs of improvement. The UAE has suspended trade with Iran, while France and Saudi Arabia are set to discuss pipeline and rail alternatives to bypass the strait.

The Donald Trump administration is preparing unprecedented financial sanctions aimed at pressuring Iran’s leadership. Tehran has warned that any new U.S. threats would trigger a crushing and devastating response.

Iran Threatens Devastating Retaliation

Iranian military officials responded with threats of broad retaliation on Friday. Major General Ali Abdollahi, chief of staff of Iran’s Armed Forces, said the country is prepared to respond across multiple domains.

"With preparedness across land, sea, air, air defense and cyberspace, Iran’s armed forces will respond to the enemy’s new threats with crushing, punishing and devastating responses," Abdollahi said, according to Iranian media.

Iran retains missile and drone capabilities that could threaten regional targets and disrupt shipping through the strategically important Strait of Hormuz.

China, Oil Markets Face Fallout

The sanctions could have consequences beyond Iran. China purchases more than 80% of Iran’s shipped oil, according to Kpler data, making Beijing a key target of Washington’s pressure campaign. China’s embassy in Washington rejected sanctions as a solution, saying they would not resolve the issue and urging diplomacy instead.

Oil prices rose Friday as markets assessed the possibility of tighter supplies and further disruptions around Hormuz.

Iranian Parliament Speaker Mohammad Baqer Qalibaf acknowledged the economic strain, saying Iran cannot survive without financial activity, economic growth and domestic production.

The U.S. and Iran have previously announced ceasefire agreements aimed at restoring shipping through Hormuz, but navigation remains heavily disrupted.

US Plans Toughest Sanctions Yet Against Iran

The comments came after U.S. Treasury Secretary Scott Bessent said Washington will impose the "toughest sanctions in history" on Iran, with more details expected Monday.

Trump warned that countries providing Iran with "any type of lifeline" could face economic consequences as the administration seeks to isolate Tehran financially.

Bessent said the goal is to intensify economic pressure on Iran’s leadership, telling CNBC, "We are going to collapse this regime."

The new measures come as the U.S.-Iran war approaches its six-month mark.